In contrast, both delta-8-THC and delta-9-THC significantly reduced the incidence of seizures on the first and second days of administration. The interictal peaks during this period, on the other hand, actually improved. Epilepsy is considered to be one of the most common noncommunicable neurological diseases, especially in low- and middle-income countries. Approximately one-third of patients with epilepsy have seizures that are resistant to antiepileptic drugs.
Clinical trials for the treatment of drug-refractory epilepsy have focused mainly on new pharmacological treatments and have resulted in a significant proportion of subjects whose seizures remain drug-resistant. The unauthorized use of the cannabis sativa plant in the treatment of seizures has been known since ancient times. The active ingredients in this plant are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), the latter considered safer and more effective in treating seizures, and with less adverse psychotropic effects. Ivan Soltesz and his colleagues have discovered that a marijuana-like compound in the brain calms epileptic seizures but also increases memory loss, Steve Fisch.